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Head and Neck Cancers: Results of Thermoradiotherapy Versus Radiotherapy
Sixty-five patients were included in a randomized clinical study to evaluate the efficacy of local hyperthermia as a concomitant agent to radiotherapy in the treatment of carcinoma of the head and neck region. Local hyperthermia at 42-43°C was generated by a 27 – 12...
Electro-Hyperthermia for Refractory Ovarian Cancer Patient having Bone Marrow Depletion as a Consequence of Long-Term Chemotherapy: Case Report
Modulated electro-hyperthermia is an emerging complementary treatment option for refractory solid tumor. Early experience suggests that it may have advantages over conventional hyperthermia with exceeding efficacy, and less complication. Herein, we describe a case of...
Combined Chemoradiotherapy with Local Microwave Hyperthermia for Treatment of T3N0 Laryngeal Carcinoma: a Retrospective Study with Long-Term Follow-Up
The purpose of our study was to test the efficacy and toxicity of hyperthermia in conjunction with chemoradiotherapy for T3N0 laryngeal cancer. From 1997-2006, 25 patients diagnosed with T3N0 laryngeal carcinoma who denied laryngectomy were selected for this...
Clinical Study for Advanced Pancreas Cancer Treated by Oncothermia
Pancreas cancer (PCA) is an aggressive, common malignant tumor. We present two retrospective clinical studies of PCA done in two medical centers (HTT-MED Day-clinic and Peterfy Hospital). Both of the centers made the treatments by oncothermia in combination with the...
Clinical Study for Advanced Non-Small-Cell Lung-Cancer Treated by Oncothermia
The non-small-cell-lung-cancer (NSCLC) is a common malignant tumor, and generally not best candidates for hyperthermia due to the cooling effect of the breathing. We present two retrospective clinical studies for NSCLC done by two medical centers (HTT-MED Day-clinic...
Vitamin C Use in Cancer – Continuous IVC Infusion, A Novel Approach
The full scope of action for intravenous vitamin C (IVC) is yet to be discovered. As we continue to learn more novel mechanisms of intravenous vitamin C, the clinical potential of this therapy continues to evolve. It is common practice in the integrative oncology...
High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy
Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two cancer clinical trials, ascorbate was abandoned by conventional oncology but continued...
Skin Photoaging and the Role of Antioxidants in Its Prevention
Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage,UVR activates cell surface receptors of keratinocytes and fibroblasts in the...
Potential Mechanisms of Action for Vitamin C in Cancer
Whether vitamin C (ascorbate) has a role to play as an anti-cancer agent has been debated for decades. Ascorbate has been used by cancer patients in an unregulated environment, either as a dietary supplement or in pharmacological doses administered by infusion, with...
Local Tumor Hyperthermia as Immunotherapy for Metastatic Cancer
Local tumour hyperthermia for cancer treatment is currently used either for ablation purposes as an alternative to surgery or less frequently, in combination with chemotherapy and/or radiation therapy to enhance the effects of those traditional therapies. As it has...
First Results of Triple-Modality Treatment Combining Radiotherapy, Chemotherapy, and Hyperthermia for the Treatment of Patients with Stage IIB, III, and IVA Cervical Carcinoma
BACKGROUND. Patients with advanced cervical carcinoma are treated routinely with radiotherapy and cisplatin-containing chemotherapy. It has been shown that hyperthermia can improve the results of both radiotherapy and cisplatin. In the current study, the feasibility...
Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discoveries
A concentration-function approach to vitamin C (ascorbate) has yielded new physiology and pharmacology discoveries. To determine the range of vitamin C concentrations possible in humans, pharmacokinetics studies were conducted. They showed that when vitamin C is...
Intravenous Vitamin C and Cancer: A Systematic Review
Background. Intravenous vitamin C (IVC) is a contentious adjunctive cancer therapy, widely used in naturopathic and integrative oncology settings. We conducted a systematic review of human interventional and observational studies assessing IVC for use in cancer...
High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
We report a case of regression of multiple pulmonary metastases, which originated from hepatocellular carcinoma after treatment with intravenous administration of high-dose vitamin C. A 74-year-old woman presented to the clinic for her cancer-related symptoms such as...
Expression and/or Activity of the SVCT2 Ascorbate Transporter may be Decreased in many Aggressive Cancers, Suggesting Potential Utility for Sodium Bicarbonate and Dehydroascorbic Acid in Cancer Therapy
Hypoxia-inducible factor-1 (HIF-1) is a heterodimer transcription factor whose elevated activity in many cancers helps them to survive under hypoxic conditions and enhances their capacity to grow invasively, establish metastases, and survive chemo- or radiotherapy....
Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
Adipose tissue is now considered as an endocrine organ involved in metabolic and inflammatory reactions. Adiponectin, a 244–amino acid peptide hormone, is associated with insulin resistance and carcinogenesis. Curcumin (diferuloylmethane) is the principal curcuminoid...
Locoregional Hyperthermia Combined with Chemotherapy for Metastatic Breast Cancer Parients
Background: Treatment options for patients with metastatic breast cancer should be both as effective and preferably as little toxic as possible. However to date there is no standard therapy available but treatment regimens for metastatic breast cancer vary much....
Hyperthermia and Radiation for Head and Neck Cancers
Abstract Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose...
