Modulated electro-hyperthermia is an emerging complementary treatment option for refractory solid tumor. Early experience suggests that it may have advantages over conventional hyperthermia with exceeding efficacy, and less complication. Herein, we describe a case of platinum-resistant, refractory ovarian cancer successfully controlled by the combination of electro-hyperthermia and dose-dense chemotherapy. On the way of repeated treatment for advanced or relapsed ovarian cancer, we finally encountered uncontrollable tumor growth simultaneously with multi-drug resistance and bone-marrow depletion. In this case, we observed stable disease over long time (1 year <) without any significant hematologic complications by applying electro-hyperthermia and weekly single chemo-agent. The gross lesion was disappeared on CT scan and PET imaging with the decline of serum CA-125 marker. Electro-hyperthermia combined with dose-dense chemotherapy could be a good treatment option for the selected, refractory ovarian cancer patients without significant hematologic complications.
