Obesity is a well-known risk factor for colorectal cancer, but the exact connections between the two conditions are not fully understood. A groundbreaking project is using untargeted metabolomics, focusing on small molecules, to uncover the ‘metabolic signatures’ associated with obesity and their relationship with colorectal cancer.
While we acknowledge the link between obesity and colorectal cancer, the specific mechanisms behind it remain mysterious. Weight loss has been shown to reduce cancer risk, prompting a closer examination of how metabolites (small molecules), vital in colorectal cancer development, react to weight loss. This study has the potential to reveal innovative strategies for preventing cancer.
The project aims to identify “metabolic signatures” related to obesity using untargeted metabolomics, a technique that assesses thousands of blood metabolites simultaneously. It also seeks to understand how these obesity-related metabolites respond to weight loss, providing insights into critical metabolic pathways at the intersection of obesity and cancer.
Leveraging data from the EPIC study, encompassing thousands of cancer-free participants, the project will analyze metabolite concentrations in correlation with body mass index (BMI) and other obesity metrics. Identified metabolites will then be tested in a separate sample series to assess their association with colorectal cancer risk. A case-control study within EPIC will compare blood samples collected before cancer diagnosis, unraveling the colorectal cancer risk linked to obesity-associated metabolites.
This study aims to identify blood metabolites associated with obesity and various weight loss strategies. By understanding how these metabolites correlate with colorectal cancer risk, the research aims to shed light on underlying mechanisms and metabolic pathways. The insights gained could guide policies for preventing colorectal cancer, marking a significant leap forward in understanding and managing the complex interplay between obesity and cancer.
If you or someone you know is navigating colorectal cancer, or if you’re at high risk due to family history, personal IBD history, or weight concerns, schedule a consultation today to learn how our team can be a part of your wellness journey.
